Antigen presentation by MHC-E: a putative target for vaccination?
Antigen presentation by MHC-E: a putative target for vaccination?
复制标题
DOI：
10.1016/j.it.2022.03.002
复制
发表时间：
2022-05
影响因子：
16.8
通讯作者：
Joosten, Simone A.
中科院分区：
文献类型：
--
作者：
Voogd, Linda;Ruibal, Paula;Ottenhoff, Tom H. M.;Joosten, Simone A.
The essentially monomorphic human antigen presentation molecule HLA-E is an interesting candidate target to enable vaccination irrespective of genetic diversity. Predictive HLA-E peptide-binding motifs have been refined to facilitate HLA-E peptide discovery. HLA-E can accommodate structurally divergent peptides from self and microbial origin. Intracellular processing and presentation pathways for peptides by HLA-E for T cell receptor recognition remain to be elucidated. Recent studies show that, unlike canonical peptides, transporter associated with antigen presentation (TAP)-inhibition is essential for HLA-E antigen presentation in Cytomegalovirus infection and possibly also for other non-canonical peptides. Here, we propose three alternative and TAP-independent MHC-E antigen presentation pathways, including for Mycobacterium tuberculosis infections. These insights may help design potential HLA-E targeting vaccines against tumors and pathogens.
登录
查看更多内容
影响因子：
7.2
作者：
Doorduijn EM;Sluijter M;Marijt KA;Querido BJ;van der Burg SH;van Hall T
通讯作者：
van Hall T
DOI：
10.1126/science.aac9475
发表时间：
2016-02-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hansen SG;Wu HL;Burwitz BJ;Hughes CM;Hammond KB;Ventura AB;Reed JS;Gilbride RM;Ainslie E;Morrow DW;Ford JC;Selseth AN;Pathak R;Malouli D;Legasse AW;Axthelm MK;Nelson JA;Gillespie GM;Walters LC;Brackenridge S;Sharpe HR;López CA;Früh K;Korber BT;McMichael AJ;Gnanakaran S;Sacha JB;Picker LJ
通讯作者：
Picker LJ
影响因子：
3.4
作者：
Houben, Diane;Demangel, Caroline;Peters, Peter J.
通讯作者：
Peters, Peter J.
影响因子：
5.4
作者：
Abdulhaqq, Shaheed A.;Wu, Helen;Sacha, Jonah B.
通讯作者：
Sacha, Jonah B.
影响因子：
64.5
作者：
André P;Denis C;Soulas C;Bourbon-Caillet C;Lopez J;Arnoux T;Bléry M;Bonnafous C;Gauthier L;Morel A;Rossi B;Remark R;Breso V;Bonnet E;Habif G;Guia S;Lalanne AI;Hoffmann C;Lantz O;Fayette J;Boyer-Chammard A;Zerbib R;Dodion P;Ghadially H;Jure-Kunkel M;Morel Y;Herbst R;Narni-Mancinelli E;Cohen RB;Vivier E
通讯作者：
Vivier E