Mesolimbic white matter connectivity mediates the preference for sweet food
Mesolimbic white matter connectivity mediates the preference for sweet food
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DOI：
10.1038/s41598-019-40935-6
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发表时间：
2019-03-13
影响因子：
4.6
通讯作者：
Brassen, Stefanie
中科院分区：
文献类型：
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作者：
Francke, Paul;Tiedemann, Lena J.;Brassen, Stefanie
伏隔核（NAc）等多巴胺能大脑结构被认为编码可口食物的刺激显着性，从而激发食欲行为。动物研究已经确定了介导享乐进食调节的神经网络，其中包括 NAc 与腹侧被盖区 (VTA) 和外侧下丘脑 (LH) 的连接。在这里，我们研究了这些途径的结构连通性如何与人类甜食消费决策的个体差异相关。因此，我们将 45 名隔夜禁食的瘦至超重参与者的扩散成像数据的概率纤维束成像与有关高糖和低糖食物消耗的真实决策结合起来。在所有个体中，糖偏好和连接强度并不直接相关，然而，多元回归分析显示中脑边缘结构和糖偏好之间的相互作用取决于个体的 BMI 评分。在超重个体（BMI：>= 25 kg/m(2)，N= 22）中，较高的糖偏好与 VTA-NAc 通路内更强的连接性特别相关，而在 BMI 正常的参与者中出现相反的模式（BMI：
Dopaminergic brain structures like the nucleus accumbens (NAc) are thought to encode the incentive salience of palatable foods motivating appetitive behaviour. Animal studies have identified neural networks mediating the regulation of hedonic feeding that comprise connections of the NAc with the ventral tegmental area (VTA) and the lateral hypothalamus (LH). Here, we investigated how structural connectivity of these pathways relates to individual variability in decisions on sweet food consumption in humans. We therefore combined probabilistic tractography on diffusion imaging data from 45 overnight fasted lean to overweight participants with real decisions about high and low sugar food consumption. Across all individuals, sugar preference and connectivity strength were not directly related, however, multiple regression analysis revealed interaction of mesolimbic structure and sugar preference to depend on individuals' BMI score. In overweight individuals (BMI: >= 25 kg/m(2), N= 22) higher sugar preference was thereby specifically related to stronger connectivity within the VTA-NAc pathway while the opposite pattern emerged in participants with normal BMI (BMI: