Urinary prostasin: a possible biomarker for renal pressure natriuresis in black adolescents.
Urinary prostasin: a possible biomarker for renal pressure natriuresis in black adolescents.
复制标题
尿前列腺素：黑人青少年肾压利尿的可能生物标志物。
DOI：
10.1203/pdr.0b013e3181994b85
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发表时间：
2009-04
影响因子：
3.6
通讯作者：
Dong Y
中科院分区：
文献类型：
--
作者：
Zhu H;Chao J;Guo D;Li K;Huang Y;Hawkins K;Wright N;Stallmann-Jorgensen I;Yan W;Harshfield GA;Dong Y
Prostasin is a membrane-bound/secretive serine protease interacting with aldosterone and the epithelial sodium channel in the kidney. We and others have previously proposed the concept of stress-induced pressure natriuresis (SIPN) where increased urinary sodium excretion (UNaV) is coupled with elevated blood pressure (BP) in response to behavioral stress in normotensive adolescents. This study thus aimed to test the relationship between prostasin and pressure natriuresis using the SIPN model. A cohort of 102 normotensive black adolescents (mean age: 17.0±1.2 years; 56% females) were placed on a controlled sodium (4000±200 mg/day) and potassium (2600±200 mg/day) diet for three days before testing. The SIPN protocol consisted of a one-hour baseline period, a one-hour stress period (competitive video games), and a one-hour recovery period. During the stress period, BP elevation was coupled with an increase in UNaV. Urinary prostasin concentration had more than a two-fold reduction from baseline (38.4±32.7 ng/ml) to stress (17.2±16.0 ng/ml), and further declined during recovery (12.1±16.2 ng/ml) (p<0.001). Urinary prostasin was inversely correlated with UNaV during stress (r=−0.43, p=0.0001), even after being normalized by urinary creatinine. Our data suggest that urinary prostasin could be a novel biomarker and/or mechanism for renal pressure natriuresis in normotensive black adolescents.
