Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans
Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans
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DOI：
10.1161/strokeaha.115.009044
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发表时间：
2015-08-01
期刊：
影响因子：
8.3
通讯作者：
Fornage, Myriam
中科院分区：
文献类型：
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作者：
Carty, Cara L.;Keene, Keith L.;Fornage, Myriam
背景和目的-大多数脑卒中的全基因组关联研究（GWAS）都集中在欧洲血统人群;然而，没有一项研究是在非裔美国人中进行的，尽管非裔美国人的脑卒中负担不成比例地高。少数民族人群全基因组卒中关联研究联合会（COMPASS）旨在确定少数民族人群中的卒中易感基因位点。方法：使用METAL，我们对来自COMPASS的14746例非裔美国人（1365例缺血性和1592例完全卒中病例）进行了GWAS荟萃分析，并使用P
Background and Purpose-The majority of genome-wide association studies (GWAS) of stroke have focused on European-ancestry populations; however, none has been conducted in African Americans, despite the disproportionately high burden of stroke in this population. The Consortium of Minority Population Genome-Wide Association Studies of Stroke (COMPASS) was established to identify stroke susceptibility loci in minority populations.Methods-Using METAL, we conducted meta-analyses of GWAS in 14 746 African Americans (1365 ischemic and 1592 total stroke cases) from COMPASS, and tested genetic variants with P