Surrogate-based visualization and sensitivity analysis of coronary stent performance: A study on the influence of geometric design
Surrogate-based visualization and sensitivity analysis of coronary stent performance: A study on the influence of geometric design
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DOI：
10.1002/cnm.3125
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发表时间：
2018-10-01
影响因子：
2.1
通讯作者：
Rodrigues, Helder C.
中科院分区：
文献类型：
--
作者：
Ribeiro, Nelson S.;Folgado, Joao;Rodrigues, Helder C.
本数值研究的主要目的是评估几何设计扰动对代表性冠状动脉支架平台性能的影响。在这种情况下，首先，为研究中的支架定义设计参数化模型。之后，在有限元分析的背景下评价了一组表征支架性能的指标，即血管损伤、径向回缩、抗弯曲性、纵向阻力、径向强度、断裂风险、脱垂指数和狗骨化。之后，使用高效的全局优化算法开发了准确的代理模型，作为执行通常需要大量模型评估的任务的预测工具，例如全局灵敏度分析和可视化。最后，输出响应面对几何参数的依赖性被机械地解释，这使我们能够理解所考虑的设计变量和定义的性能指标之间存在的复杂的相互作用。
The main goal of this numerical study is to assess the impact of geometric design perturbations on the performance of a representative coronary stent platform. In this context, first, a design parameterization model was defined for the stent under study. After, a set of metrics characterizing stent performance, namely, vessel injury, radial recoil, bending resistance, longitudinal resistance, radial strength, the risk of fracture, prolapse index, and dogboning were evaluated within the context of a finite element analysis. Afterwards, accurate surrogate models were developed, using the efficient global optimization algorithm, as predictive tools in the execution of tasks that normally require a high number of model evaluations, such as global sensitivity analysis and visualization. In the end, the dependence of the output response surfaces on the geometric parameters was mechanically interpreted, which allowed us to understand the complex interplay that exists between the considered design variables and the defined performance metrics.