COMPARISON OF SURVIVAL PROBABILITIES FOR DIALYSIS PATIENTS VS CADAVERIC RENAL-TRANSPLANT RECIPIENTS
COMPARISON OF SURVIVAL PROBABILITIES FOR DIALYSIS PATIENTS VS CADAVERIC RENAL-TRANSPLANT RECIPIENTS
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DOI：
10.1001/jama.270.11.1339
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发表时间：
1993-09-15
影响因子：
120.7
通讯作者：
JIANG, KH
中科院分区：
文献类型：
--
作者：
PORT, FK;WOLFE, RA;JIANG, KH
客观。-在环孢素时代，比较尸体肾移植受者与接受透析的移植候选人之间的死亡风险。通过治疗方式对全州范围内的患者人群进行了患者死亡风险分析。所有年龄小于65岁的密歇根州居民在1984年1月1日至1989年12月31日期间开始终末期肾病（ESRD）治疗。患者从ESRD发病（n=5020），到等待肾移植（n=1569），到接受尸体首次移植（n=799），到1989年12月31日进行随访。死亡率。结果。-使用基于从等待登记到移植的等待时间的时间依赖变量，并调整年龄、性别、种族和ESRD的主要原因，移植后早期死亡的相对风险（RR）增加，然后降低至有利的长期效应，考虑到移植后365天的存活率（RR，0.36; P
Objective.-To compare mortality risk among cadaveric renal transplant recipients vs transplant candidates on dialysis in the cyclosporine era.Setting.-Patient mortality risk was analyzed by treatment modality for a completed statewide patient population.Patients.-All Michigan residents younger than age 65 years who started end-stage renal disease (ESRD) therapy between January 1, 1984, and December 31, 1989, were included. Patients were followed up from ESRD onset (n=5020), to wait-listing for renal transplant (n=1569), to receiving a cadaveric first transplant (n=799), and to December 31, 1989.Main Outcome Measure.-Mortality rates.Results.-Using a time-dependent variable based on the waiting time from date of wait-listing to transplantation and adjusting for age, sex, race, and primary cause of ESRD, the relative risk (RR) of dying was increased early after transplantation and then decreased to a beneficial long-term effect, given survival to 365 days after transplantation (RR, 0.36; P