Ultrafast high-pressure AC electro-osmotic pumps for portable biomedical microfluidics
Ultrafast high-pressure AC electro-osmotic pumps for portable biomedical microfluidics
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DOI：
10.1039/b915979g
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发表时间：
2010-01-01
期刊：
影响因子：
6.1
通讯作者：
Thorsen, Todd
中科院分区：
文献类型：
--
作者：
Huang, Chien-Chih;Bazant, Martin Z.;Thorsen, Todd
本文详细介绍了用于稀释电解质的集成交流电渗 (ACEO) 微流体泵的开发，该泵由内衬三维 (3D) 阶梯式电极阵列的长蛇形微通道组成。该泵在水中使用低交流电压（1 V rms，1 kHz）、功率（5 mW）和电流（4.5 mA），能够产生 1.3 kPa 的水头压力，比之前的 ACEO 泵增加了 100 倍，并且在电极上产生 1.3 mm/s 的有效滑移速度，而不会出现流动逆转。集成的ACEO泵可以利用低离子强度溶液（例如蒸馏水）作为工作溶液，在单独的微流体装置中泵送生理强度（100 mM）的生物溶液，在便携式或植入式生物医学微流体装置中具有潜在的应用。作为概念验证实验，展示了在微流体微阵列中使用 ACEO 泵进行 DNA 杂交。
This paper details the development of an integrated AC electro-osmotic (ACEO) microfluidic pump for dilute electrolytes consisting of a long serpentine microchannel lined with three dimensional (3D) stepped electrode arrays. Using low AC voltage (1 V rms, 1 kHz), power (5 mW) and current (4.5 mA) in water, the pump is capable of generating a 1.3 kPa head pressure, a 100-fold increase over prior ACEO pumps, and a 1.3 mm/s effective slip velocity over the electrodes without flow reversal. The integrated ACEO pump can utilize low ionic strength solutions such as distilled water as the working solution to pump physiological strength (100 mM) biological solutions in separate microfluidic devices, with potential applications in portable or implantable biomedical microfluidic devices. As a proof-of-concept experiment, the use of the ACEO pumps for DNA hybridization in a microfluidic microarray is demonstrated.