A Review of Epidemiological Research on Adverse Neurological Effects of Exposure to Ambient Air Pollution.
A Review of Epidemiological Research on Adverse Neurological Effects of Exposure to Ambient Air Pollution.
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DOI：
10.3389/fpubh.2016.00157
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发表时间：
2016
影响因子：
5.2
通讯作者：
Basnet R
中科院分区：
文献类型：
--
作者：
Xu X;Ha SU;Basnet R
越来越多的流行病学研究报告了环境空气污染对神经系统的影响。我们检查了当前的证据，确定了已发表的流行病学研究的优点和缺点，并提出了该领域的未来研究方向。除了从已确定的论文中手动搜索参考文献列表之外，还通过系统搜索在线科学数据库来确定研究。尽管这是一个相对较新的研究领域，但总体而言，越来越多的证据表明空气污染对成人和儿童的神经行为功能产生不利影响。需要进一步的研究来扩大我们对这些关系的理解，包括提高暴露评估的准确性；重点关注特定毒物及其与特定健康终点的关系，例如神经发育障碍和神经退行性疾病；研究多种空气污染物对神经系统的综合影响；并进一步探讨空气污染神经毒性的遗传易感性。为了实现这些目标，需要包括毒理学、生物统计学、地理科学、流行病学和神经病学专家在内的多学科团队的共同努力。
There is a growing body of epidemiological research reporting the neurological effects of ambient air pollution. We examined current evidence, identified the strengths and weaknesses of published epidemiological studies, and suggest future directions for research in this area. Studies were identified through a systematic search of online scientific databases, in addition to a manual search of the reference lists from the identified papers. Despite being a relatively new area of investigation, overall, there is mounting evidence implicating adverse effects of air pollution on neurobehavioral function in both adults and children. Further research is needed to expand our understanding of these relationships, including improvement in the accuracy of exposure assessments; focusing on specific toxicants and their relationships to specific health endpoints, such as neurodevelopmental disorders and neurodegenerative diseases; investigating the combined neurological effects of multiple air pollutants; and further exploration of genetic susceptibility for neurotoxicity of air pollution. In order to achieve these goals collaborative efforts are needed from multidisciplinary teams, including experts in toxicology, biostatistics, geographical science, epidemiology, and neurology.