Group-level and functional-region analysis of electric-field shape during cerebellar transcranial direct current stimulation with different electrode montages
Group-level and functional-region analysis of electric-field shape during cerebellar transcranial direct current stimulation with different electrode montages
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DOI：
10.1088/1741-2552/ab0ac5
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发表时间：
2019-06-01
影响因子：
4
通讯作者：
Hirata, Akimasa
中科院分区：
文献类型：
--
作者：
Gomez-Tames, Jose;Asai, Akihiro;Hirata, Akimasa
客观的。小脑经颅直流电刺激 (ctDCS) 是一种向小脑传递小电流的神经调节方案。在这项工作中，我们通过计算研究 ctDCS 期间刺激剂量的分布和强度，目的是确定一组具有不同电极蒙太奇的受试者的目标小脑区域。方法。我们使用了一种新的个体间配准方法，该方法首次允许将计算电场（EF）从个体真实头部模型（n = 18）投影到标准小脑模板。主要结果。小脑表面 EF 的变化被发现具有高达平均值的 55% 的标准偏差。占最大 EF 变异性 62% 的主导因素是皮肤-小脑距离，而脑脊液量则解释了平均 EF 分布的 53%。尽管个体间存在差异，但在群体水平分析中，活性电极下方出现了 EF 热点的系统趋势。热点可以通过电极位置进行调整，以便将最有效的刺激传递给一组受试者。意义。用 ctDCS 瞄准特定的小脑结构并不简单，因为神经调节不仅取决于电极配置的放置/设计，还取决于由于解剖差异而导致的个体间差异。所提出的方法允许将 EF 推广到小脑图谱。该图谱对于研究 ctDCS 机制、规划 ctDCS 和解释实验研究结果非常有用。
Objective. Cerebellar transcranial direct current stimulation (ctDCS) is a neuromodulation scheme that delivers a small current to the cerebellum. In this work, we computationally investigate the distributions and strength of the stimulation dosage during ctDCS with the aim of determining the targeted cerebellar regions of a group of subjects with different electrode montages. Approach. We used a new inter-individual registration method that permitted the projection of computed electric fields (EFs) from individual realistic head models (n = 18) to standard cerebellar template for the first time. Main results. Variations of the EF on the cerebellar surface were found to have standard deviations of up to 55% of the mean. The dominant factor that accounted for 62% of the variability of the maximum EFs was the skin- cerebellum distance, whereas the cerebrospinal fluid volume explained 53% of the average EF distribution. Despite the inter-individual variations, a systematic tendency of the EF hotspot emerges beneath the active electrode in group-level analysis. The hotspot can be adjusted by the electrode position so that the most effective stimulation is delivered to a group of subjects. Significance. Targeting specific cerebellar structures with ctDCS is not straightforward, as neuromodulation depends not only on the placement/design of the electrodes configuration but also on inter-individual variability due to anatomical differences. The proposed method permitted generalizing the EFs to a cerebellum atlas. The atlas is useful for studying the mechanisms of ctDCS, planning ctDCS and explaining findings of experimental studies.