Mesopore to Macropore Transformation of Metal-Organic Framework for Drug Delivery in Inflammatory Bowel Disease
Mesopore to Macropore Transformation of Metal-Organic Framework for Drug Delivery in Inflammatory Bowel Disease
复制标题
用于炎症性肠病药物输送的金属有机框架的中孔到大孔的转变。
DOI：
10.1002/adhm.202000973
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发表时间：
2021
影响因子：
10
通讯作者：
Song Y.
中科院分区：
文献类型：
--
作者：
Yin Y;Yang J;Pan Y;Gao Y;Huang L;Luan X;Lin Z;Zhu W;Li Y;Song Y.
炎症性肠病（IBD）是一种以节段性肠道炎症为特征的慢性复发性自身免疫性疾病。迫切需要更有效的炎症靶向策略来提高治疗效果并减少全身药物暴露。在本文中，报道了氧化响应性金属有机框架材料（Ce-MOF @PSS），其通过灌肠优先粘附于发炎的肠。在炎症部位过度产生的活性氧（ROS）诱导Ce-MOF @PSS从中孔转化为大孔，并伴有局部药物释放。在实验性结肠炎中，Ce-MOF @PSS递送系统在抑制炎症和修复肠屏障功能方面表现出优异的炎症靶向功效和优于游离药物的上级治疗效果。因此，通过靶向肠道炎症，增加局部药物浓度，清除ROS，减少全身暴露，并表现出优异的安全性特征，认为Ce-MOF药物递送平台可以作为用于IBD和其他炎性疾病管理的转化纳米医学而被深入开发。
Inflammatory bowel disease (IBD) is a chronic relapsing autoimmune disease that is characterized by segmental intestinal inflammation. There is an urgent need for more efficient inflammation‐targeting strategies to improve therapeutic effect and reduce systemic drug exposure. Herein, an oxidation‐responsive metal–organic framework material (Ce‐MOF@PSS) is reported that preferentially adheres to inflamed intestine via enema. The overproduced reactive oxygen species (ROS) at inflammatory sites induces transformation of Ce‐MOF@PSS from mesopore to macropore with local drug release. In experimental colitis, the Ce‐MOF@PSS delivery system exhibits excellent inflammation‐targeting efficacy and superior therapeutic effect over free drug on suppressing inflammation and repairing intestinal barrier function. Accordingly, by targeting intestinal inflammation, increasing local drug concentrations, scavenging ROS, reducing systemic exposure, and exhibiting excellent safety profiles, it is considered that the Ce‐MOF drug delivery platform can be intensively developed as a translational nanomedicine for the management of IBD and other inflammatory diseases.