Predominant emphysema phenotype in chronic obstructive pulmonary disease patients
Predominant emphysema phenotype in chronic obstructive pulmonary disease patients
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DOI：
10.1183/09031936.03.00048703
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发表时间：
2003-03-01
影响因子：
24.3
通讯作者：
Mapp, CE
中科院分区：
文献类型：
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作者：
Boschetto, P;Miniati, M;Mapp, CE
固定气流受限的患者被归类为慢性阻塞性肺疾病（COPD）。作者调查了COPD患者是否有不同的功能，放射学和痰细胞特征取决于是否存在肺气肿。24例COPD门诊患者，12例肺气肿和12例无肺气肿的高分辨率计算机断层扫描的胸部，进行了检查。结果：肺气肿组与非肺气肿组比较，第一秒用力呼气量（FEV 1）、FEV 1/用力肺活量比值（FEV 1/FEV 1）、一氧化碳弥散常数（KCO）均明显降低。肺气肿患者的胸片评分较高，慢支胸片评分较低，痰中淋巴细胞计数增加，且KCO与肺气肿患者的肺功能呈负相关。慢性阻塞性肺疾病相关表型的识别可能会提高对疾病自然史和治疗的理解。
Patients with fixed airflow limitation are grouped under the heading of chronic obstructive pulmonary disease (COPD). The authors investigated whether COPD patients have distinct functional, radiological and sputum cells characteristics depending on the presence or absence of emphysema.Twenty-four COPD outpatients, 12 with and 12 without emphysema on high-resolution computed tomography scan of the chest, were examined. Patients underwent chest radiography, pulmonary function tests and sputum induction and analysis.Subjects with documented emphysema had lower forced expiratory volume in one second (FEV1), FEV1/forced vital capacity ratio, and lower carbon monoxide diffusion constant (KCO), compared with subjects without emphysema. Chest radiograph score of emphysema was higher, chest radiograph score of chronic bronchitis was lower, and the number of sputum lymphocytes was increased in patients with emphysema, who also showed a negative correlation between KCO and pack-yrs.Chronic obstructive pulmonary disease patients with emphysema, documented by high-resolution computed tomography scan, have a different disease phenotype compared with patients without emphysema. Identification of chronic obstructive pulmonary disease-related phenotypes may improve understanding of the natural history and treatment of the disease.