Population genetics -: Malaria susceptibility and CD36 mutation
Population genetics -: Malaria susceptibility and CD36 mutation
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DOI：
10.1038/35016636
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发表时间：
2000-06-29
期刊：
影响因子：
64.8
通讯作者：
Scott, J
中科院分区：
文献类型：
--
作者：
Aitman, TJ;Cooper, LD;Scott, J
恶性疟原虫是导致最严重疟疾的微生物，感染恶性疟原虫的一个关键步骤是寄生的红细胞与毛细血管内皮细胞的粘连。人蛋白CD36是P的主要受体。感染了恶性疟原虫的红细胞，并可能通过隔离感染的红细胞，抑制对寄生虫的免疫反应而导致疾病。我们发现，非洲人群中CD36突变的频率非常高。出乎意料的是，这些导致CD36缺乏症的突变与严重疟疾的易感性有关，这表明非洲人和亚洲人中存在独特的CD36突变是由于疟疾以外的一些选择压力。
A critical step in infection byPlasmodium falciparum, the microorganism that causes the most severe form of malaria, is the adhesion of parasitized red blood cells to capillary endothelium. The human protein CD36 is a major receptor forP. falciparum-infected red blood cells,and may contribute to the disease by sequestering infected red blood cells,and inhibiting the immune response to the parasite. We have found that African populations contain an exceptionally high frequency of mutations in CD36. Unexpectedly, these mutations that cause CD36 deficiency are associated with susceptibility to severe malaria, suggesting that the presence of distinctCD36mutations in Africans and Asians,,is due to some selection pressure other than malaria.