Suppression of puberty in rats by exercise: effects on hormone levels and reversal with GnRH infusion.
Suppression of puberty in rats by exercise: effects on hormone levels and reversal with GnRH infusion.
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运动抑制大鼠青春期：对激素水平的影响以及 GnRH 输注的逆转。
DOI：
10.1152/ajpregu.1991.260.4.r717
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Bronson,FH
中科院分区：
文献类型：
--
作者：
Manning,JM;Bronson,FH
为了更好地了解长时间运动对下丘脑-垂体-卵巢轴的影响，我们对两个治疗组的年轻雌性大鼠进行了各种比较：1）长时间运动，在青春期前阶段，通过要求大鼠长时间奔跑以获得食物来抑制生长和生殖发育； 2）自愿运动，其中同龄对照大鼠随意喂食并自由使用跑轮。长时间的运动治疗完全抑制了黄体生成素（LH）和生长激素的脉动分泌。促卵泡激素、催乳素和促甲状腺激素的平均水平不受影响。长时间的运动会提高皮质酮的滴度，并且这种类固醇的分泌模式会随着跑步活动而发生变化。长时间运动会增强而不是抑制下丘脑中促性腺激素释放激素 (GnRH) 和垂体中 LH 的组织水平。最重要的是，GnRH 的脉冲输注恢复了仍受到长期运动治疗限制生长的大鼠的正常青春期发育和排卵。这项研究的结果表明，长时间运动的抑制作用在某种程度上影响了下丘脑 GnRH 脉冲发生器信号的产生。
In an effort to better understand the effects of prolonged exercise on the hypothalamic-pituitary-ovarian axis, we made a variety of comparisons between young female rats in two treatment groups: 1) prolonged exercise, in which growth and reproductive development were arrested at a peripubertal stage by requiring rats to run for long periods of time in order to obtain food; and 2) voluntary exercise, in which same-aged control rats were fed ad libitum and given free access to a running wheel. The pulsatile secretion of luteinizing hormone (LH) and growth hormone were completely suppressed by the prolonged exercise treatment. Mean levels of follicle-stimulating hormone, prolactin, and thyroid-stimulating hormone were not affected. Prolonged exercise elevated corticosterone titers, and the secretory pattern of this steroid was changed out of phase with running activity. Tissue levels of gonadotropin-releasing hormone (GnRH) in the hypothalamus and LH in the pituitary were enhanced, not suppressed, by prolonged exercise. Most importantly, pulsatile infusions of GnRH reinstated normal pubertal development and ovulation in rats still growth restricted by the prolonged exercise treatment. The results of this study indicate that the suppressive effects of prolonged exercise somehow affect the production of the hypothalamic GnRH-pulse generator signal.