Circulating periostin levels increase in association with bone density loss and healing progression during the early phase of hip fracture in Chinese older women
Circulating periostin levels increase in association with bone density loss and healing progression during the early phase of hip fracture in Chinese older women
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DOI：
10.1007/s00198-017-4034-z
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发表时间：
2017-08-01
影响因子：
4
通讯作者：
Yang, X. F.
中科院分区：
文献类型：
--
作者：
Yan, J.;Liu, H. J.;Yang, X. F.
本研究表明，髋部骨折妇女血清骨膜蛋白（sPostn）水平较高。升高的sPostn与骨密度损失，但骨折本身甚至可能增加sPostn水平在早期愈合phase.Introduction本研究的目的是量化协会的sPostn水平与骨密度损失和可能的影响上的骨折愈合。方法本研究纳入了261老年妇女骨质疏松性髋部骨折和106年龄匹配的妇女作为对照组没有骨折。骨折后2天内测量临床特征、骨密度（BMD）和骨转换标志物（包括sPostn水平）。随访sPostn水平在1年后2 days可为128 patients.Results骨折后的sPostn的初始水平显着高于对照组的患者。在整个队列中，sPostn与股骨颈BMD（r =-0.529，P < 0.001）、I型胶原β异构C端交联（r = 0.403，P = 0.008）和I型胶原N端前胶原（r = 0.236，P = 0.042）相关。多因素分析后，sPostn仍然是股骨颈BMD的独立危险因素，可解释BMD变异的19.1%。骨折后7天内的sPostn从第2天开始急剧增加，然后下降，并在360天维持在略高的水平。骨折后第7天sPostn的百分比变化与β-CTX（r = 0.396，P = 0.002）和PINP（r = 0.180，P = 0.033）的变化呈正相关。结论高sPostn水平是老年女性急性髋部骨折股骨颈BMD的独立预测因子。在早期愈合阶段增加的sPostn水平可能暗示Postn在骨修复中发挥作用。
The Summary The present study shows that hip fracture women had higher serum periostin (sPostn) levels. The elevation of sPostn is associated with bone density loss, yet fracture itself may even increase sPostn levels during early healing phase.Introduction The study aims to quantify the associations of sPostn levels with bone density loss and the possible effect on the fracture healing.Methods This study enrolled 261 older women with osteoporotic hip fracture and 106 age-matched women without fracture serving as controls. Clinical features, bone mineral density (BMD), and bone turnover markers including sPostn level were measured after fracture within 2 days. Follow-up sPostn levels during 1 year after 2 days were available for 128 patients.Results Initial levels of sPostn after fracture were significantly higher in patients than controls. sPostn was correlated with BMD of femoral neck (r = -0.529, P < 0.001), beta-isomerized C-terminal crosslinking of type I collagen (beta-CTX) (r = 0.403, P = 0.008), and N-terminal procollagen of type I collagen (PINP) (r = 0.236, P = 0.042) in the entire cohort. After multivariate analysis, sPostn remained as an independent risk factor for femoral neck BMD, which explained 19.1% of the variance in BMD. sPostn sampled within 7 days after fracture were acutely increasing from day 2 and then decreased and maintained at slightly high levels at 360 days. The percentage changes of sPostn positively correlated with the variation in beta-CTX (r = 0.396, P = 0.002) and PINP (r = 0.180, P = 0.033) at day 7 after fracture.Conclusions High sPostn levels were an independent predictor of femoral neck BMD in older women presenting with an acute hip fracture. Increased sPostn levels during early healing phase may imply that Postn play a role in bone repair.