Peripheral hypoxia in restless legs syndrome (Willis-Ekbom disease)
Peripheral hypoxia in restless legs syndrome (Willis-Ekbom disease)
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DOI：
10.1212/wnl.0000000000000454
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发表时间：
2014-05-27
期刊：
影响因子：
9.9
通讯作者：
Polo, Olli
中科院分区：
文献类型：
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作者：
Salminen, Aaro V.;Rimpila, Ville;Polo, Olli
目的：一项病例对照研究，测量腿部的氧分压和二氧化碳分压，以评估外周缺氧或高碳酸血症在不宁腿综合征 (RLS) 发病机制中的参与情况。方法：通过标准问卷评估 RLS 的严重程度。建议对 15 名 RLS 患者和 14 名健康对照者进行两次固定测试。患有 RLS 的患者在使用或不使用普拉克索药物的情况下参加了测试。测试期间，在腿部和胸部皮肤上无创地测量了外周氧和二氧化碳分压。结果：在固定期间，RLS 患者腿部的氧分压较低（5.54 vs 7.19 kPa，p
Objective: A case-control study to measure oxygen and carbon dioxide partial pressures in the legs in order to assess the involvement of peripheral hypoxia or hypercapnia in the pathogenesis of restless legs syndrome (RLS).Methods: RLS severity was assessed with a standard questionnaire. Suggested immobilization tests were performed twice in 15 patients with RLS and 14 healthy controls. Patients with RLS participated in the tests with and without pramipexole medication. During the tests, peripheral oxygen and carbon dioxide partial pressures were measured noninvasively on the skin of the legs and the chest.Results: During immobilization, the patients with RLS had lower partial pressure of oxygen in their legs (5.54 vs 7.19 kPa, p