Plasma insulin and lipoprotein concentrations: an atherogenic association?
Plasma insulin and lipoprotein concentrations: an atherogenic association?
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血浆胰岛素和脂蛋白浓度：导致动脉粥样硬化的关联？
DOI：
10.1093/oxfordjournals.aje.a113639
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发表时间：
1983
影响因子：
5
通讯作者：
Drash,AL
中科院分区：
文献类型：
--
作者：
Orchard,TJ;Becker,DJ;Bates,M;Kuller,LH;Drash,AL
Orchard, t.j.（公共卫生研究生院，Pittsburgh, PA 15261）， d.j. Becker， M. Bates， L. H. Kuller和A. L. Drash。血浆胰岛素和脂蛋白浓度：是否与动脉粥样硬化有关？[J]流行病学杂志1983；118: 326 - 37。血浆胰岛素浓度已被证明是男性未来心血管疾病的预测指标。尽管许多临床研究证明血浆胰岛素和甘油三酯浓度之间存在相关性，但很少有流行病学研究报道胰岛素-脂质相关性。在本报告中，作者介绍了1980年2月至1981年12月期间在宾夕法尼亚州匹兹堡儿童医院接受4小时口服葡萄糖耐量试验的胰岛素依赖型糖尿病患者的323名非糖尿病一级亲属的相关性，作为胰岛素依赖型糖尿病流行病学研究的一部分。胰岛素（以空腹胰岛素和口服糖耐量试验时胰岛素曲线下3小时面积测量）与致动脉粥样硬化脂质、总胆固醇和低密度脂蛋白胆固醇和甘油三酯之间的相关性为+0.14 （p < 0.01）至+0.35 （p < 0.001）。与高密度脂蛋白胆固醇呈负相关，dr= -0.27 （p < 0.001）。计算出的胰岛素活性得分，作者称之为胰岛素-葡萄糖敏感性指数，显示出同样强的相关性，但呈相反的迹象。在多变量分析中，这些胰岛素测量和年龄在很大程度上解释了性别和肥胖（以体重指数衡量）与致动脉粥样硬化脂质的关系，尽管这对高密度脂蛋白胆固醇只有部分正确。讨论了这些发现的生物学合理性及其与动脉粥样硬化发展的相关性。
Orchard, T. J. (Graduate School of Public Health, Pittsburgh, PA 15261), D. J. Becker, M. Bates, L. H. Kuller and A. L. Drash. Plasma insulin and lipoprotein concentrations: an atherogenic association?Am J Epidemiol1983; 118: 326–37.Plasma insulin concentrations have been shown to be predictive of future cardiovascular disease in men. Though many clinical studies have documented correlations between plasma insulin and triglyceride concentrations, few epi-demiologic studies have reported insulin-lipid correlations. In this report, the authors present correlations obtained from 323 non-diabetic first degree relatives of insulin dependent diabetic patients who underwent 4 hour oral glucose tolerance tests at Children's Hospital, Pittsburgh, Pennsylvania, in February 1980-December 1981 as part of an epidemiologic study of insulin dependent diabetes mellitus. Significant positive correlations were seen between insulin (measured as fasting insulin and the 3 hour area under the insulin curve during the oral glucose tolerance test) and the atherogenic lipids, total and low density lipoprotein cholesterol and triglycerides ranging fromr= +0.14 (p < 0.01) tor= +0.35 (p < 0.001). An inverse correlation with high density lipoprotein cholesterol was also notedr= -0.27 (p < 0.001). A computed score of insulin activity, which the authors call the insulin-glucose sensitivity index, shows equally strong correlations but of reverse sign. In multivariate analyses, these insulin measures and age largely account for the associations of sex and obesity (measured as body mass index) with the atherogenic lipids, though this was only partly true for high density lipoprotein cholesterol. The biologic plausibility of these findings and their relevance to the development of atherosclerosis are discussed.