EXPRESSION OF THE FIBRONECTIN GENE
EXPRESSION OF THE FIBRONECTIN GENE
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DOI：
10.1165/ajrcmb/1.1.5
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发表时间：
1989-07-01
影响因子：
6.4
通讯作者：
DEAN, DC
中科院分区：
文献类型：
--
作者：
DEAN, DC
纤连蛋白（FN）是一种细胞外基质蛋白，在发育过程中充当细胞迁移和粘附的底物。FN通过二聚体膜蛋白FN受体粘附于细胞。FN抗体和抑制FN-受体相互作用的合成肽抑制原肠胚形成，阻断神经嵴细胞迁移，阻止心脏发育，并阻断成肌细胞融合形成肌管。FN及其受体似乎对肺发育也很重要，它们的表达与分支形态发生的开始一致，但在成人肺中降至几乎检测不到的水平，表明发育特异性。FN在大多数成人组织中的表达通常较低。然而，在损伤和伤口愈合期间，合成急剧增加，这是一个在许多方面模仿发育的过程。FN的合成也急剧增加，在纤维增生性肺病变与主要结构的变化，在肺。
Fibronectin (FN) is an extracellular matrix protein that acts as a substrate for cell migration and adhesion during development. FN adheres to cells through a dimeric membrane protein, the FN receptor. Antibodies to FN and synthetic peptides that inhibit FN-receptor interaction inhibit gastrulation, block neural crest cell migration, arrest cardiac development, and block the fusion of myoblasts to form myotubes. FN and its receptor also appear to be important for lung development, where their expression coincides with the onset of branching morphogenesis, but drops to barely detectable levels in adult lung, indicating developmental specificity. FN expression is generally low in most adult tissues. However, synthesis is drastically increased during injury and wound healing, a process that in many ways mimics development. FN synthesis is also drastically increased in fibroproliferative lung lesions associated with major architectural changes in the lung.