The Impact of Chemical Probes in Drug Discovery: A Pharmaceutical Industry Perspective
The Impact of Chemical Probes in Drug Discovery: A Pharmaceutical Industry Perspective
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DOI：
10.1016/j.chembiol.2015.11.011
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发表时间：
2016-01-21
影响因子：
8.6
通讯作者：
Parmee, Emma R.
中科院分区：
文献类型：
--
作者：
Garbaccio, Robert M.;Parmee, Emma R.
化学探针是学术和药物发现研究的重要组成部分。作为对定义这一科学领域的先前综述的补充，我们的目标是提供一个行业视角，了解在整个临床前研究过程中拥有高质量化学探针的价值。通过研究默克公司内部管道的例子，我们认识到这些探针需要大量的合作投资，以实现其在澄清给定治疗靶点的易处理性和翻译方面的潜在影响。这一观点的结论与化学探针发现的建议，旨在最大限度地发挥其潜力，以确定目标，导致成功交付的新疗法。
Chemical probes represent an important component of both academic and pharmaceutical drug discovery research. As a complement to prior reviews that have defined this scientific field, we aim to provide an industry perspective on the value of having high-quality chemical probes throughout the course of preclinical research. By studying examples from the internal Merck pipeline, we recognize that these probes require significant collaborative investment to realize their potential impact in clarifying the tractability and translation of a given therapeutic target. This perspective concludes with recommendations for chemical probe discovery aimed toward maximizing their potential to identify targets that result in the successful delivery of novel therapeutics.