Familial multiple sclerosis: Clinical, histocompatibility, and viral serological studies
Familial multiple sclerosis: Clinical, histocompatibility, and viral serological studies
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家族性多发性硬化症：临床、组织相容性和病毒血清学研究
DOI：
10.1002/ana.410030111
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发表时间：
1978
影响因子：
11.2
通讯作者：
H. Krebs
中科院分区：
文献类型：
--
作者：
R. Eldridge;H. McFarland;J. Sever;D. Sadowsky;H. Krebs
对假定的“多发性硬化症家庭”的评估以及与最近报告的家庭的比较使我们得出以下观察结果：（1）由于家庭成员的个人临床评估未能证实第二位近亲的诊断，我们最初的 14 个假定的多发性硬化症家庭中的 7 个不得不被排除。 (2) 在我们的七个真正的多发性硬化症家族中，没有注意到受影响和未受影响的个体之间存在 HLA 类型分离，并且在其他地方报道的 28 个家族中也没有注意到一致的分离。这支持了其他遗传证据，即 HLA 复合体中不存在单一的主要基因图谱，该基因易患多发性硬化症。 (3) DW 2 抗原在我们家庭受影响成员中的频率增加，并且 A3 B7 单倍型在报告的其他家庭受影响成员中更常见。但未受影响的成员也往往具有这些相同抗原的频率增加。 (4)我们家中没有发现HLA类型与抗麻疹抗体滴度之间存在关系。
Evaluation of presumed “multiple sclerosis families” and comparison with recently reported families has led us to the following observations: (1) Seven of our original fourteen presumptive multiple sclerosis families had to be eliminated after personal clinical evaluation of family members failed to confirm the diagnosis in a second close relative. (2) No segregation of HLA type was noted between affected and unaffected individuals in our seven bona fide multiple sclerosis families, and no consistent segregation was noted in the twenty‐eight families reported elsewhere. This supports other genetic evidence that there is not a single, major gene mapping in the HLA complex which predisposes to multiple sclerosis. (3) The DW 2 antigen was increased in frequency among affected members of our families, and the A3 B7 haplotype was more frequent among affected members of other families reported. But unaffected members also tended to have an increased frequency of these same antigens. (4) No relationship was noted between HLA type and antimeasles antibody titer within our families.