The effect of HAART on salivary microbiota in the women's interagency HIV study (WIHS)
The effect of HAART on salivary microbiota in the women's interagency HIV study (WIHS)
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DOI：
10.1016/j.tripleo.2004.10.011
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发表时间：
2005-12-01
期刊：
影响因子：
--
通讯作者：
Slots, J
中科院分区：
文献类型：
--
作者：
Navazesh, M;Mulligan, R;Slots, J
objective.在妇女跨部门艾滋病研究中，研究艾滋病病毒阳性妇女唾液中潜在致病微生物的流行情况。157名HIV阳性和31名HIV阴性妇女接受了研究。在基线和4年中每6个月，收集有关社会经济和教育状况，口腔和全身健康，包括艾滋病毒市场和抗逆转录病毒治疗，以及专业口腔护理使用频率的信息。采用标准方法对刺激的全唾液中的细菌和酵母致病性分离株进行初步鉴定。HIV阳性妇女刺激唾液中微生物的流行率与HIV阴性妇女无显著差异。在HIV阳性女性中，高效抗逆转录病毒治疗（HAART）与多种唾液细菌的存在独立且显著相关。HAART增加了梭杆菌属恢复的风险（P
Objective. Study the prevalence of potentially pathogenic microorganisms in saliva of HIV-positive women in the Women's Interagency HIV Study.Study design. 157 HIV-positive and 31 HIV-negative women were studied. At baseline and every 6 months over 4 years, information was collected on socioeconomic and educational status, oral and systemic health, including HIV markets and antiretroviral therapy, and frequency of professional oral care utilization. Bacterial and yeast pathogenic isolates from stimulated whole saliva were tentatively identified using standard methodologies.Results. The prevalence of microorganisms in stimulated saliva of HIV-positive women was not significantly different from that of HIV-negative women. In HIV-positive women, highly active antiretroviral therapy (HAART) was independently and significantly associated with the presence of a variety of salivary bacterial species. HAART increased the risk for recovering Fusobacterium species (P