Protective and pathogenic memory plasma cells
Protective and pathogenic memory plasma cells
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DOI：
10.1016/j.imlet.2017.04.014
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发表时间：
2017-09-01
影响因子：
4.4
通讯作者：
Radbruch, Andreas
中科院分区：
文献类型：
--
作者：
Hoyer, Bimba F.;Radbruch, Andreas
免疫系统可分为两个主要部分：先天免疫和适应性免疫。适应性免疫的特征在于其主要的细胞参与者：B和T细胞。在免疫反应的情况下，B细胞将分化成浆细胞。这些浆细胞产生分泌的抗体。抗体的特征在于其对所选抗原的特异性及其同种型。同种型随着免疫反应的持续时间或阶段而变化。早期免疫反应通常以IgM抗体的主要产生为特征。随着免疫反应的持续，发生免疫球蛋白类别转换，并且浆细胞将产生IgG、IgE或IgA抗体（Radbruch等人，2006年）[1]。
The immune system can be divided into two major parts: innate and adaptive immunity. Adaptive immunity is characterized by its major cellular players: the B and T cells. B cells will, in the context of an immune reaction, differentiate into plasma cells. These plasma cells produce antibodies, which are secreted. Antibodies are characterized by their specificity against a selected antigen and by their isotype. The isotype changes with the duration or phase of the immune reaction. Early immune reactions are usually characterized by the predominant production of IgM antibodies. With the persistence of the immune reaction immunoglobulin class switch occurs and plasma cells will produce IgG, IgE or IgA-antibodies (Radbruch et al., 2006) [1].