Evaluation of psychopathological conditions in children with heavy prenatal alcohol exposure
Evaluation of psychopathological conditions in children with heavy prenatal alcohol exposure
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DOI：
10.1542/peds.2006-1606
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发表时间：
2007-03-01
期刊：
影响因子：
8
通讯作者：
Mattson, Sarah N.
中科院分区：
文献类型：
--
作者：
Fryer, Susanna L.;McGee, Christie L.;Mattson, Sarah N.
客观的。本研究比较了产前大量饮酒的儿童 (N = 39) 和未接触过酒精的、典型发育中的同龄人 (N = 30) 的精神病理状况的患病率，并与年龄、性别和社会经济地位相匹配。方法。护理人员接受了《学龄儿童情感障碍和精神分裂症儿童时间表》当前和终身版本或《儿童计算机化诊断访谈时间表》第四版的访谈。使用统计重采样方法为暴露组和对照组中患有精神病理状况的儿童比例之间的差异创建 95% 置信区间。 结果。注意力缺陷/多动障碍、抑郁障碍、对立违抗障碍、行为障碍和特定恐惧症结果类别存在组间差异。注意力缺陷/多动障碍类别的群体差异是迄今为止观察到的最大效应。结论。这些结果表明，胎儿酒精暴露应被视为儿童精神疾病发病机制的一个可能因素。这些数据提供了有关胎儿酒精暴露儿童可能面临的心理健康问题的临床相关信息。
OBJECTIVE. This study compared the prevalence of psychopathological conditions in children with heavy prenatal alcohol exposure ( N = 39) and nonexposed, typically developing peers ( N = 30), matched with respect to age, gender, and socioeconomic status.METHODS. Caregivers were interviewed with either the Kiddie Schedule for Affective Disorders and Schizophrenia for School- Age Children, Present and Lifetime Version, or the Computerized Diagnostic Interview Schedule for Children, Version IV. Statistical resampling methods were used to create 95% confidence intervals for the difference between the proportions of children with psychopathological conditions in the exposed and control groups.RESULTS. Group differences were seen in the attention- deficit/ hyperactivity disorder, depressive disorders, oppositional defiant disorder, conduct disorder, and specific phobia outcome categories. The group difference in the attention- deficit/ hyperactivity disorder category was by far the largest effect observed.CONCLUSIONS. These results suggest that fetal alcohol exposure should be considered a possible factor in the pathogenesis of childhood psychiatric disorders. These data provide clinically relevant information about the mental health problems that children with fetal alcohol exposure are likely to face.