Insecticidal Toxin Complexes from Photorhabdus luminescens.
Insecticidal Toxin Complexes from Photorhabdus luminescens.
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DOI：
10.1007/82_2016_55
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发表时间：
2017
影响因子：
--
通讯作者：
J. Sheets;K. Aktories
中科院分区：
文献类型：
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作者：
J. Sheets;K. Aktories
各种细菌毒素都有很强的杀虫活性。近年来，光hahabdusa和xenorhabdusa物种的毒素复合物（Tc’s）已成为当前研究的热点。这些分子质量为140兆道尔顿的大型三方毒素由三种成分组成，称为A、B和C（或TcA、TcB和TcC）。虽然TcA参与受体结合和毒素易位，但TcC具有特异性毒素酶活性，TcB是TcA和TcC组分之间的连接体。本文对Tc毒素的结构功能进行了分析，并讨论了Tc毒素作为潜在杀虫剂的应用。
Various bacterial toxins have potent insecticidal activity. Recently, the Toxin complexes (Tc’s) ofPhotorhabdusandXenorhabdusspecies have become an increased focus of current research. These large tripartite toxins with molecular masses >1.4 megadaltons consist of three components termed A, B, and C (or TcA, TcB, and TcC). While TcA is involved in receptor binding and toxin translocation, TcC possesses the specific toxin enzyme activity and TcB is a linker between components TcA and TcC. Here, a structure function analysis of the toxins is described and the application of Tc toxins as potential insecticides is discussed.