High normal HbA1c levels were associated with impaired insulin secretion without escalating insulin resistance in Japanese individuals: the Toranomon Hospital Health Management Center Study 8 (TOPICS 8)
High normal HbA1c levels were associated with impaired insulin secretion without escalating insulin resistance in Japanese individuals: the Toranomon Hospital Health Management Center Study 8 (TOPICS 8)
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DOI：
10.1111/j.1464-5491.2012.03667.x
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发表时间：
2012-10-01
影响因子：
3.5
通讯作者：
Sone, H.
中科院分区：
文献类型：
--
作者：
Heianza, Y.;Arase, Y.;Sone, H.
糖尿病Med.29，12851290（2012）摘要目的我们旨在表征在没有临床诊断的糖尿病的日本个体中，胰岛素抵抗、胰岛素分泌受损和β细胞功能障碍与非糖尿病范围内的HbA 1c水平的相关性。方法这项横断面研究包括1444名没有糖尿病门诊治疗史或使用胰岛素或口服降糖药的患者。使用75 g口服葡萄糖耐量试验的数据计算胰岛素抵抗和β细胞功能的稳态模型评估、胰岛素生成指数、Matsuda指数和处置指数，并在HbA 1c水平的五分位数（Q）类别之间进行比较。结果当HbA 1c超过36 mmol/mol时，空腹血糖、30 min和60 min血糖（PG）水平显著升高（5.4%）。与HbA 1c = 32 mmol/mol（= 5.1%）（Q1）相比，HbA 1c浓度3637 mmol/mol（5.45.5%）（Q3）与稳态模型评估的β细胞功能值降低15%和胰岛素生成指数值降低31%显著相关（P
Diabet. Med. 29, 12851290 (2012) Abstract Aims We aimed to characterize the association of insulin resistance, impaired insulin secretion and beta-cell dysfunction in relation to HbA1c levels in a non-diabetic range in Japanese individuals without clinically diagnosed diabetes. Methods This cross-sectional study included 1444 individuals without a history of outpatient treatment of diabetes or use of insulin or oral hypoglycaemic agents. The homeostasis model assessment of insulin resistance and beta-cell function, insulinogenic index, Matsuda index and disposition index were calculated using data from 75-g oral glucose tolerance tests and compared across quintile (Q) categories of HbA1c levels. Results Fasting plasma glucose and 30-min and 60-min plasma glucose (PG) levels were significantly higher when HbA1c exceeded 36 mmol/mol (5.4%). A HbA1c concentration of 3637 mmol/mol (5.45.5%) (Q3) was significantly associated with a 15% lower homeostasis model assessment of beta-cell function value and 31% lower insulinogenic index value compared with HbA1c = 32 mmol/mol (= 5.1%) (Q1) (P