Understanding the catch-bond kinetics of biomolecules on a one-dimensional energy landscape
Understanding the catch-bond kinetics of biomolecules on a one-dimensional energy landscape
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DOI：
10.1038/s42004-019-0131-6
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发表时间：
2019-03-13
影响因子：
5.9
通讯作者：
Yan, Jie
中科院分区：
文献类型：
--
作者：
Guo, Shiwen;Efremov, Artem K.;Yan, Jie
尽管进行了广泛的研究，但生物分子的力依赖性展开/断裂速率k（F）仍然知之甚少。一个著名的例子是经常观察到的从捕捉键行为的转变，其中力反直观地减小k（F），到滑动键行为，其中增加力加速k（F）。在该领域的一个共同的共识是，捕捉到滑动开关的行为不能解释在一个一维的能量景观，而这种观点主要是建立在假设力单调影响k（F）沿着每个可用的过渡路径。在这项工作中，通过将Kramers动力学速率理论应用于模型系统，其中过渡从单个原生状态开始，通过涉及聚合物链的顺序剥离的路径，直到达到过渡状态，我们表明捕获到滑动开关行为可以通过考虑过渡期间分子的结构弹性性质在一维能量景观中理解。因此，这项工作加深了我们对分子/分子复合物的力依赖性展开/断裂动力学的理解。
In spite of extensive investigations, the force-dependent unfolding/rupturing rate k(F) of biomolecules still remains poorly understood. A famous example is the frequently observed switch from catch-bond behaviour, where force anti-intuitively decreases k(F), to slip-bond behaviour where increasing force accelerates k(F). A common consensus in the field is that the catch-to-slip switch behaviour cannot be explained in a one-dimensional energy landscape, while this view is mainly built upon assuming that force monotonically affects k(F) along each available transition pathway. In this work, by applying Kramers kinetic rate theory to a model system where the transition starts from a single native state through a pathway involving sequential peeling of a polymer strand until reaching the transition state, we show the catch-to-slip switch behaviour can be understood in a one-dimensional energy landscape by considering the structural-elastic properties of molecules during transition. Thus, this work deepens our understanding of the force-dependent unfolding/rupturing kinetics of molecules/molecular complexes.