Modulation of endogenous hormone action by recombinant human tumor necrosis factor.
Modulation of endogenous hormone action by recombinant human tumor necrosis factor.
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重组人肿瘤坏死因子对内源激素作用的调节。
DOI：
10.1073/pnas.84.23.8619
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发表时间：
1987
影响因子：
11.1
通讯作者：
Brennan,MF
中科院分区：
文献类型：
--
作者：
Warren,RS;Donner,DB;StarnesJr,HF;Brennan,MF
肿瘤坏死因子（TNF）与压倒性细菌感染的毒性表现以及经常伴随长期感染和恶性肿瘤的组织浪费有关。我们研究了TNF在急性组织损伤或脓毒症后早期代谢改变中的可能作用。重组人TNF刺激大鼠肝脏氨基酸摄取高达5倍，在体内，有一个伴随的血浆胰高血糖素的增加。体外TNF对肝细胞氨基酸摄取无直接影响，但显著增强胰高血糖素对氨基酸转运的刺激作用，而胰高血糖素与肝细胞的结合无改变。TNF对胰高血糖素作用的这种容许效应代表了免疫系统和内分泌系统之间的相互关系，并且它可能有助于解释对急性损伤的合成代谢和分解代谢反应的激素调节机制。
Tumor necrosis factor (TNF) has been implicated in the toxic manifestations of overwhelming bacterial infection and in the tissue wasting that often accompanies prolonged infections and malignancy. We have examined a possible role of TNF in the early metabolic alterations following acute tissue injury or sepsis. Recombinant human TNF stimulated rat liver amino acid uptake up to 5-fold in vivo and there was a concomitant increase in plasma glucagon. In vitro TNF had no direct effect on hepatocyte amino acid uptake, but it markedly enhanced the stimulation of amino acid transport by glucagon, without an alteration in binding of glucagon to hepatocytes. This permissive effect of TNF on glucagon action represents an interrelationship between the immune and endocrine systems, and it may help to explain the mechanism of hormonal regulation of both the anabolic and catabolic responses to acute injury.