EXPRESSION OF THE MAJOR NEUROFILAMENT SUBUNIT IN CHICKEN ERYTHROCYTES
EXPRESSION OF THE MAJOR NEUROFILAMENT SUBUNIT IN CHICKEN ERYTHROCYTES
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DOI：
10.1126/science.6346488
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
LAZARIDES, E
中科院分区：
文献类型：
--
作者：
GRANGER, BL;LAZARIDES, E
在鸡红细胞中检测到了神经丝的70，000-道尔顿核心多肽，它被认为只存在于神经元中，在那里它与波形蛋白和synemin共存，作为中间丝网络的一种成分。它存在于胚胎和幼龄鸡的循环红系细胞中，但在成年鸡的红系细胞中几乎不存在。这些发现与目前的中间丝表达模型不一致，但提供了神经系统和造血系统之间意想不到的相似性的另一个例子。
The 70,000-dalton core polypeptide of neurofilaments, thought to exist only in neurons, was detected in chicken erythrocytes, where it coexists with vimentin and synemin as a component of the intermediate filament network. It is present in the circulating erythroid cells of embryos and young chickens but is nearly absent from the erythroid cells of adults. These findings are inconsistent with current models of intermediate filament expression, but provide another example of unexpected similarities between the nervous and hemopoietic systems.