Synthesis of the N-((1E)-alkenyl)-(2Z,4Z)-heptadienamide side chain of salicylihalamide A and apicularens A and B.
Synthesis of the N-((1E)-alkenyl)-(2Z,4Z)-heptadienamide side chain of salicylihalamide A and apicularens A and B.
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DOI：
10.1021/ol991388
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发表时间：
2000-01
期刊：
影响因子：
5.2
通讯作者：
B. Snider;F. Song
中科院分区：
文献类型：
--
作者：
B. Snider;F. Song
[反应：见文]在一个锅中加入(1Z,3Z)-六烯基铜酸盐原位制备的水杨柳卤酰胺A(1)和apicularens A和B（3和4）的不稳定N-（(1E)-烯基）-(2Z,4Z)-七烯酰胺侧链。SMe2和乙炔合成(1e)-烯基异氰酸酯。
[reaction: see text] The unstable N-((1E)-alkenyl)-(2Z,4Z)-heptadienamide side chain of salicylihalamide A (1) and apicularens A and B (3 and 4) has been prepared in one pot by the addition of (1Z,3Z)-hexadienylcuprate, prepared in situ from EtLi, CuBr.SMe2, and acetylene, to a (1 E)-alkenyl isocyanate.