Identification of Environmental Chemicals Associated with the Development of Toxicant-associated Fatty Liver Disease in Rodents.
Identification of Environmental Chemicals Associated with the Development of Toxicant-associated Fatty Liver Disease in Rodents.
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DOI：
10.1177/0192623314549960
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发表时间：
2015-06
影响因子：
1.5
通讯作者：
Cave M
中科院分区：
文献类型：
--
作者：
Al-Eryani L;Wahlang B;Falkner KC;Guardiola JJ;Clair HB;Prough RA;Cave M
毒物相关性脂肪性肝病(TAFLD)是新近发现的一种与工业化学品和环境污染物暴露相关的非酒精性脂肪性肝病(NAFLD)。在体内和体外，已经进行了大量的研究来测试工业化学品/环境污染物与脂肪肝的相关性。本文件的目的是报告与TAFLD有关的化学品清单。搜索两个啮齿动物毒理学研究的联邦数据库-ToxRefDB(环境保护局)和化学效应在生物系统(CEBS，国家毒理学计划)的肝脏终点。这两个数据库加在一起，存档了近2000项啮齿动物研究。TASH描述包括脂肪改变、脂肪坏死、油红O阳性染色、脂肪变性和脂肪沉积。使用这些搜索词，识别出123种与脂肪肝有关的化学物质。杀虫剂和溶剂是最常被发现的化学物质，而多氯联苯/二恶英是最有效的。大约44%的已鉴定化合物是农药或其中间体，ToxRefDB上近10%的农药注册研究与脂肪肝有关。与杀虫剂相比，杀菌剂和除草剂更常与脂肪肝有关。对NAFLD/TAFLD中的杀虫剂、溶剂、金属和多氯联苯/二恶英进行更多的研究，因为它们与肝脏损害有关。
Toxicant associated fatty liver disease (TAFLD) is a recently identified form of non-alcoholic fatty liver disease (NAFLD) associated with exposure to industrial chemicals and environmental pollutants. Numerous studies have been conducted to test the association between industrial chemicals/ environmental pollutants and fatty liver disease both in vivo and in vitro. The objective of the paper is to report a list of chemicals associated with TAFLD. Two federal databases of rodent toxicology studies– ToxRefDB (Environmental Protection Agency) and Chemical Effects in Biological Systems (CEBS, National Toxicology Program) were searched for liver endpoints. Combined, these two databases archive nearly 2000 rodent studies. TASH descriptors including fatty change, fatty necrosis, Oil red O positive staining, steatosis and lipid deposition were queried. Using these search terms, 123 chemicals associated with fatty liver were identified. Pesticides and solvents were the most frequently identified chemicals, while PCBs/dioxins were the most potent. About 44% of identified compounds were pesticides or their intermediates, and nearly 10% of pesticide registration studies in ToxRefDB were associated with fatty liver. Fungicides and herbicides were more frequently associated with fatty liver than insecticides. More research on pesticides, solvents, metals and PCBs/dioxins in NAFLD/TAFLD is warranted due to their association with liver damage.