The danger model: A renewed sense of self
The danger model: A renewed sense of self
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DOI：
10.1126/science.1071059
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发表时间：
2002-04-12
期刊：
影响因子：
56.9
通讯作者：
Matzinger, P
中科院分区：
文献类型：
--
作者：
Matzinger, P
50多年来，免疫学家的思想、实验和临床治疗都是基于这样一种观点，即免疫系统通过区分自我和非我来发挥作用。尽管这种模式常常很好地为我们服务，但多年的详细检查揭示了一些固有的问题。这一观点概述了一种基于免疫系统更关心造成损害的实体而不是外来实体的免疫模型。
For over 50 years immunologists have based their thoughts, experiments, and clinical treatments on the idea that the immune system functions by making a distinction between self and nonself. Although this paradigm has often served us well, years of detailed examination have revealed a number of inherent problems. This Viewpoint outlines a model of immunity based on the idea that the immune system is more concerned with entities that do damage than with those that are foreign.