Three-dimensional chitosan-nanohydroxyapatite composite scaffolds for bone tissue engineering
Three-dimensional chitosan-nanohydroxyapatite composite scaffolds for bone tissue engineering
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DOI：
10.1007/s11837-009-0131-6
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发表时间：
2009-09
期刊：
影响因子：
2.6
通讯作者：
W. Thein-Han;R. Misra
中科院分区：
文献类型：
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作者：
W. Thein-Han;R. Misra
我们描述了可生物降解的壳聚糖-纳米羟基磷灰石（nHA）复合支架的结构及其与骨组织工程中的前成骨细胞的相互作用。支架是通过冷冻和冻干制造的。纳米复合材料支架的特点是具有高度多孔结构，孔径约为 50-125 μm，与 nHA 含量无关。与纯壳聚糖相比，纳米复合材料支架上前成骨细胞的生物反应显着增强，表现为细胞附着、增殖和广泛的形态，这表明它们有可能用作骨再生的支架材料。
We describe the structure of biodegradable chitosan-nanohydroxyapatite (nHA) composites scaffolds and their interaction with pre-osteoblasts for bone tissue engineering. The scaffolds were fabricated via freezing and lyophilization. The nanocomposite scaffolds were characterized by a highly porous structure and pore size of ∼50–125 μm, irrespective of nHA content. The observed significant enhancement in the biological response of pre-osteoblast on nanocomposite scaffolds expressed in terms of cell attachment, proliferation, and widespread morphology in relation to pure chitosan points toward their potential use as scaffold material for bone regeneration.