CONCENTRATION OF SODIUM HYALURONATE IN SERUM
CONCENTRATION OF SODIUM HYALURONATE IN SERUM
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DOI：
10.3109/00365518509155249
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发表时间：
1985-01-01
影响因子：
2.1
通讯作者：
LAURENT, TC
中科院分区：
文献类型：
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作者：
ENGSTROMLAURENT, A;LAURENT, UBG;LAURENT, TC
利用牛软骨的高亲和力结合蛋白对透明质酸钠进行了血清分析。该方法的准确性通过同位素稀释实验和外源透明质酸的回收率研究进行了验证。测定的测定间标准偏差为15-20%。健康成人（献血者）体内透明质酸钠浓度在10 ~ 100 μ之间。G /l，平均值为30 ~ 40 μ G /l。这比之前报道的浓度要低。在年轻人中也发现了同样的水平。在50岁以上的人群中，透明质酸浓度较高。血浆分析显示，其平均透明质酸水平（5%）略高于同一人的血清。性别差异不显著。对成年动物（大鼠、兔、狗、猪、山羊、绵羊、牛和马）的血清和血浆进行分析，发现透明质酸浓度与人血清相同或更高。
A radioassay for sodium hyaluronate using high-affinity binding protein from bovine cartilage had been modified for serum analysis. The accuracy of the method was checked by isotope dilution experiments and by recovery studies with exogenous hyaluronate. The between-assay standard deviation in the determination is 15-20%. The concentration of sodium hyaluronate in healthy adults (blood donors) is in the range of 10 to 100 .mu.g/l with a mean value in the order of 30 to 40 .mu.g/l. This is a lower concentration than previously reported. The same level was found in young people. Higher hyaluronate concentrations were noted in persons above 50 years of age. Analysis of plasma showed a slightly higher average hyaluronate level (5%) than in serum from the same persons. There were no notable sex differences. Analysis of serum and plasma from adult animals (rat, rabbit, dog, pig, goat, sheep, cow and horse) gave hyaluronate concentrations of the same order or higher than in human serum.