Behavioral and pharmacological determinants of drug abuse.
Behavioral and pharmacological determinants of drug abuse.
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药物滥用的行为和药理学决定因素。
DOI：
10.1111/j.1749-6632.1992.tb25982.x
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发表时间：
1992
影响因子：
5.2
通讯作者：
Barrett,JE
中科院分区：
文献类型：
--
作者：
Nader,MA;Tatham,TA;Barrett,JE
毫无疑问，药物的药理学特性在引发多种反应中发挥着重要作用，但也很明显，有几个变量可以显着改变该药物对中间过程及其对行为的最终影响的影响。本章重点讨论一些已被证明可以改变滥用药物行为影响的变量。重点是描述某些条件，在这些条件下，滥用药物的效果会因先前的行为和/或药理学经验而发生变化，通常是戏剧性的。由于这些效应已在多种滥用药物中得到证实，并且在很长一段时间内保持稳定，并且在多种条件下都可以观察到，因此这些虚构因素似乎可能与最终理解并能够干预改变导致药物滥用的条件具有直接相关性。尽管已经描述了药物行为影响的几个决定因素（例如，没有药物时的反应率、强化时间表和维持事件类型），但在评估本章的准备工作时，通常可以识别这些变量，并得到 NIDA 拨款 DA-06828、DA-06829 和 DA-
While there is little doubt that the pharmacological properties of a drug play an important role in the initiation of a multitude of responses, it is also clear that several variables can significantly alter the effects of that drug both on intermediate processes and in its ultimate effects on behavior. This chapter focuses on some of the variables that have been shown to modify the behavioral effects of abused drugs. The emphasis is on describing certain conditions under which the effects of an abused drug are changed, often dramatically, by prior behavioral and/or pharmacological experience. Because these effects have been shown with a wide variety of abused drugs, are stable over lengthy periods of time, and are observed under a broad range of conditions, it would seem that these fictors may have direct relevance for eventually understanding and being able to intercede in altering those conditions that lead to drug abuse. Although several determinants of the behavioral effects of drugs have been described (eg., rate of responding in the absence of the drug, schedule of reinforcement and type of maintaining event), these variables typically are identifiable when assessing a Preparation of this chapter was supported by NIDA grants DA-06828, DA-06829 and DA-