HEMODYNAMIC AND HYPOTENSIVE EFFECTS OF LONG-TERM THERAPY WITH CHLOROTHIAZIDE
HEMODYNAMIC AND HYPOTENSIVE EFFECTS OF LONG-TERM THERAPY WITH CHLOROTHIAZIDE
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DOI：
10.1161/01.cir.21.1.21
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发表时间：
1960-01-01
期刊：
影响因子：
37.8
通讯作者：
LAUWERS, P
中科院分区：
文献类型：
--
作者：
CONWAY, J;LAUWERS, P
观察了83例高血压病患者服用氯噻嗪的降压效果。2/3的患者血压明显下降，平均下降23/15毫米汞柱。10例测定了血浆容量，16例测定了心输出量和外周阻力。7~19天后，血浆容量和心输出量持续下降。血浆容量平均变化400ml，心脏指数平均变化0.9L/min。维持治疗1个月以上后，血浆容量与对照组相比无明显变化，心输出量与治疗前相同。直接从肱动脉测得的血压保持在较低水平，平均降低39/20 mm Hg。因此，外周阻力也有类似比例的下降。平均预处理值为1655，处理后为1265达因/秒/厘米-5。
The hypotensive effect of chlorothiazide has been investigated in 83 patients with hypertension. A significant fall in blood pressure was found in 2/3 of the patients with an average reduction in pressure of 23/15 mm Hg. Plasma volume determinations were made in 10 patients and cardiac output and peripheral resistance was measured in 16. After periods of 7 to 19 days a consistent fall in plasma volume and cardiac output was obtained. The average change in plasma volume was 400 ml and in cardiac index, 0.9 liters/min. After treatment had been maintained for periods exceeding one month no detectable change in plasma volume over the control was found and similarly, the cardiac output was the same as in the pretreatment period. The blood pressure measured directly from the brachial artery remained at a lower level, the average reduction being 39/20 mm Hg below the control period. Therefore there was a fall in peripheral resistance of similar proportions. The average pretreatment value was 1655 and after treatment it was 1265 dynes/sec./cm-5.