MATHEMATICAL-MODEL OF AN IDENTIFIED STOMATOGASTRIC GANGLION NEURON
MATHEMATICAL-MODEL OF AN IDENTIFIED STOMATOGASTRIC GANGLION NEURON
复制标题
DOI：
10.1152/jn.1992.67.2.332
复制
发表时间：
1992-02-01
影响因子：
2.5
通讯作者：
MARDER, E
中科院分区：
文献类型：
--
作者：
BUCHHOLTZ, F;GOLOWASCH, J;MARDER, E
1. 在前面的论文中描述的口胃神经节（STG）的外侧幽门（LP）细胞中的离子电流的岩蟹北巨蟹座拟合一组微分方程，描述其电压，时间和Ca 2+的依赖性。 模型化的电压依赖性电流是延迟整流器样电流i（d）; Ca 2+激活的外向电流i（o）（Ca）;瞬时A样电流i（A）; Ca 2+电流i（Ca）;内向整流电流i（h）;和快速河豚毒素（TTX）敏感的Na+电流i（Na）。 根据6个电压依赖性电流、电压非依赖性漏电流i（l）、Ca 2+缓冲系统和膜电容构建了LP细胞的单室等电位模型. 在电压钳和电流钳两种模式下，通过模拟生理实验，将模型LP神经元的行为与生物神经元的行为进行比较。 模型和生物神经元显示出相似的动作电位形状，持续时间，稳态电流-电压（I-V）曲线，并以可比的方式响应注入电流。
1. The ionic currents in the lateral pyloric (LP) cell of the stomatogastric ganglion (STG) described in the preceding paper of the rock crab Cancer borealis were fit with a set of differential equations that describe their voltage, time, and Ca2+ dependence. The voltage-dependent currents modeled are a delayed rectifier-like current, i(d); a Ca2+-activated outward current, i(o)(Ca); a transient A-like current, i(A); a Ca2+ current, i(Ca); an inwardly rectifying current, i(h); and a fast tetrodotoxin (TTX)-sensitive Na+ current, i(Na).2. A single-compartment, isopotential model of the LP cell was constructed from the six voltage-dependent currents, a voltage-independent leak current i(l), a Ca2+ buffering system, and the membrane capacitance.3. The behavior of the model LP neuron was compared with that of the biological neuron by simulating physiological experiments carried out in both voltage-clamp and current-clamp modes. The model and biological neurons show similar action-potential shapes, durations, steady-state current-voltage (I-V) curves, and respond to injected current in a comparable way.