The importance of a multidimensional approach to the preclinical study of major depressive disorder and apathy.
The importance of a multidimensional approach to the preclinical study of major depressive disorder and apathy.
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DOI：
10.1042/etls20220004
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发表时间：
2022-12-09
影响因子：
3.8
通讯作者：
中科院分区：
文献类型：
--
作者：
冷漠的神经精神综合征和重性抑郁症都包括一组跨越多个行为领域的异质性症状。尽管存在这种异质性，但临床前文献倾向于从单独使用的一维行为任务中得出MDD或冷漠样表型，这可能导致表型解释不准确。这是重要的，因为冷漠和重性抑郁症在临床上是不同的，具有不同的潜在机制和治疗方法。在临床水平上，冷漠和重性抑郁障碍可以在研究领域标准的负效价（损失）领域中分离。在负效价（损失）域中的MDD症状可以包括对情绪突出的刺激和情绪低落的夸张反应，而相比之下，冷漠的特征是情绪迟钝的状态。在这篇文章中，我们强调如何使用单维方法可以限制精神病学模型的解释。我们讨论了如何整合的积极和消极（损失）效价域的研究领域标准的行为研究结果可以有利于解释的结果。我们特别关注与负效价（损失）域相关的行为，这可能用于在临床前水平区分冷漠和重度抑郁症。最后，我们考虑如何使用家庭笼监测未来的方法可能会提供一个新的机会，以检测不同的行为配置文件，并有利于整体的可翻译性的结果。
Both the neuropsychiatric syndrome of apathy and major depressive disorder comprise a heterogenous cluster of symptoms which span multiple behavioural domains. Despite this heterogeneity, there is a tendency in the preclinical literature to conclude a MDD or apathy-like phenotype from a single dimensional behavioural task used in isolation, which may lead to inaccurate phenotypic interpretation. This is significant, as apathy and major depressive disorder are clinically distinct with different underlying mechanisms and treatment approaches. At the clinical level, apathy and major depressive disorder can be dissociated in the negative valence (loss) domain of the Research Domain Criteria. Symptoms of MDD in the negative valence (loss) domain can include an exaggerated response to emotionally salient stimuli and low mood, while in contrast apathy is characterised by an emotionally blunted state. In this article, we highlight how using a single dimensional approach can limit psychiatric model interpretation. We discuss how integrating behavioural findings from both the positive and negative (loss) valence domains of the Research Domain Criteria can benefit interpretation of findings. We focus particularly on behaviours relating to the negative valence (loss) domain, which may be used to distinguish between apathy and major depressive disorder at the preclinical level. Finally, we consider how future approaches using home cage monitoring may offer a new opportunity to detect distinct behavioural profiles and benefit the overall translatability of findings.
影响因子：
3.7
作者：
Pietersen CY;Bosker FJ;Doorduin J;Jongsma ME;Postema F;Haas JV;Johnson MP;Koch T;Vladusich T;den Boer JA
通讯作者：
den Boer JA