Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid.
Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid.
复制标题
联合使用褪黑激素和 9-顺式视黄酸对 NMU 诱导的大鼠乳腺癌进行化学预防。
DOI：
10.1016/s0304-3835(01)00548-1
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发表时间：
2001
期刊：
影响因子：
9.7
通讯作者：
Hill,SM
中科院分区：
文献类型：
--
作者：
Teplitzky,SR;Kiefer,TL;Cheng,Q;Dwivedi,PD;Moroz,K;Myers,L;Anderson,MB;Collins,A;Dai,J;Yuan,L;Spriggs,LL;Blask,DE;Hill,SM
在使用N-亚硝基-N-甲基脲（NMU）诱导的大鼠乳腺肿瘤模型的实验性试验中，与对照组（55%）相比，在用褪黑激素和9-顺式-视黄酸（9 cRA）处理的大鼠中观察到肿瘤发生率显著降低（至5%）。虽然9 cRA单独使用可将肿瘤发生率降低至26%，但这种反应未达到统计学显著性。在接受褪黑激素和9 cRA的动物中，肿瘤发生率被显著抑制至20%。与对照组相比，接受任一联合治疗的动物的肿瘤发病潜伏期延长，肿瘤多样性也显著降低。
In experimental trials using the N-nitroso-N-methylurea (NMU)-induced rat mammary tumor model, a significant decrease in tumor incidence (to 5%) was observed in rats treated with melatonin and 9-cis-retinoic acid (9 cRA) compared to controls (55%). Although 9cRA alone decreased tumor incidence to 26%, this response did not reach statistical significance. Tumor incidence was significantly inhibited to 20% in the animals that received melatonin and 9cRA on alternating days. Latency to tumor onset was prolonged in animals receiving either of the combination treatments compared with controls, and tumor multiplicity was also significantly decreased.