Diabetes vaccines: a future to be realized.
Diabetes vaccines: a future to be realized.
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糖尿病疫苗：一个有待实现的未来。
DOI：
10.1089/15209150152607222
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Maclaren,NK
中科院分区：
文献类型：
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作者：
Lin-Su,K;Kukreja,A;Maclaren,NK
免疫介导的（1 型）糖尿病 (IMD) 是一种自身免疫性疾病，由自身反应性 T 淋巴细胞对胰岛细胞的慢性破坏所致。尽管糖尿病管理取得了很大进步，但针对疾病过程的精确病因仍然难以捉摸。然而，最近对 IMD 免疫发病机制的理解取得了进展，催生了新的干预策略，特别是作为改变的肽配体 (APL) 或疫苗给予的基于抗原的疗法。抗原特异性疫苗甚至非抗原特异性免疫刺激剂不是使用免疫抑制剂来抑制已经功能失调的免疫系统，而是提供了独特的机会来增强调节功能，从而恢复对自身的耐受性。我们在此讨论 IMD 的发病机制，因为它与治疗可能性相关，回顾了在啮齿动物模型中取得成功的各种干预策略，然后介绍了通过疫苗原型干预和预防糖尿病的人体试验的最新进展。
Immune-mediated (type 1) diabetes mellitus (IMD) is an autoimmune disease resulting from the chronic destruction of pancreatic islet cells by autoreactive T lymphocytes. Although there has been much advancement in diabetes management, targeting the precise etiology of the disease process has remained elusive. Recent progress in the understanding of the immunopathogenesis of IMD, however, has led to new intervention strategies, especially antigen-based therapies given as altered peptide ligands (APLs) or as vaccines. Instead of using immunosuppressive agents to suppress an already dysfunctional immune system, antigen specific vaccines or even non-antigen specific immunostimulants present a unique opportunity to boost regulatory function and thereby regain tolerance to self. We discuss here the pathogenesis of IMD as it relates to therapeutic possibilities, review various intervention strategies that have been successful in rodent models, and then present recent progress in human trials of diabetes intervention and prevention through vaccine prototypes.