Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor
Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor
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DOI：
10.1126/science.1073031
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发表时间：
2002-08-16
期刊：
影响因子：
56.9
通讯作者：
Strittmatter, SM
中科院分区：
文献类型：
--
作者：
Liu, BP;Fournier, A;Strittmatter, SM
Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and myelin-associated glycoprotein (MAG). The receptor for Nogo (NgR) has been identified as an axonal glycosyl-phosphatidylinositol (GPI) anchored protein, whereas the MAG receptor has remained elusive. Here, we show that MAG binds directly, with high affinity, to NgR. Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse, and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth. MAG-resistant embryonic neurons are rendered MAG-sensitive by expression of NgR. MAG and Nogo-66 activate NgR independently and serve as redundant NgR ligands that may limit axonal regeneration after CNS injury.
