Hand-independent representation of tool-use pantomimes in the left anterior intraparietal cortex
Hand-independent representation of tool-use pantomimes in the left anterior intraparietal cortex
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DOI：
10.1007/s00221-016-4765-7
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发表时间：
2016-12-01
影响因子：
2
通讯作者：
Imai, Fumihito
中科院分区：
文献类型：
--
作者：
Ogawa, Kenji;Imai, Fumihito
先前对意动性失用症（IMA）的神经心理学研究表明，在左半球顶叶前运动皮层病变后，右手和左手的哑语动作工具使用受损。利用功能磁共振成像（fMRI）和多体素模式分析（MVPA），我们验证了左顶叶-运动前皮层参与工具使用动作的手无关表征的存储或检索的假设。在fMRI扫描仪中，三种工具中的一种以图片或字母的形式显示出来，参与者用右手进行图片刺激或左手进行字母刺激来模仿这些工具的使用。然后我们使用MVPA对被试模仿的工具进行分类。全脑探照灯分析显示，成功解码的活动主要集中在对侧初级感觉运动区、同侧小脑和双侧早期视觉区，这可能反映了三种类型哑剧低水平感觉运动成分的差异。此外，利用顶叶前沟交界处附近的左侧顶叶下小叶（IPL）的活动，可以成功地对右手和左手进行交叉分类。我们的发现表明，左侧顶叶内前部皮层在产生不依赖于手的、独立于刺激方式的工具使用哑剧中起着重要作用。
Previous neuropsychological studies of ideomotor apraxia (IMA) indicated impairments in pantomime actions for tool use for both right and left hands following lesions of parieto-premotor cortices in the left hemisphere. Using functional magnetic resonance imaging (fMRI) with multi-voxel pattern analysis (MVPA), we tested the hypothesis that the left parieto-premotor cortices are involved in the storage or retrieval of hand-independent representation of tool-use actions. In the fMRI scanner, one of three kinds of tools was displayed in pictures or letters, and the participants made pantomimes of the use of these tools using the right hand for the picture stimuli or with the left hand for the letters. We then used MVPA to classify which kind of tool the subjects were pantomiming. Whole-brain searchlight analysis revealed successful decoding using the activities largely in the contralateral primary sensorimotor region, ipsilateral cerebellum, and bilateral early visual area, which may reflect differences in low-level sensorimotor components for three types of pantomimes. Furthermore, a successful cross-classification between the right and left hands was possible using the activities of the left inferior parietal lobule (IPL) near the junction of the anterior intraparietal sulcus. Our finding indicates that the left anterior intraparietal cortex plays an important role in the production of tool-use pantomimes in a hand-independent manner, and independent of stimuli modality.