Dopamine and Gambling Disorder: Prospects for Personalized Treatment.
Dopamine and Gambling Disorder: Prospects for Personalized Treatment.
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多巴胺和赌博障碍：个性化治疗的前景。
DOI：
10.1007/s40429-019-00240-8
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发表时间：
2019
影响因子：
4.3
通讯作者：
Kayser,Andrew
中科院分区：
文献类型：
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作者：
Kayser,Andrew
综述的目的为了解决赌博障碍严重程度的差异，本综述评估了中皮质边缘多巴胺神经元对潜在行为内表型的贡献、多巴胺系统个体差异对赌博和相关行为的影响，以及多巴胺能药物在赌博障碍治疗中的可能作用。最新发现新的研究表明，多巴胺能功能障碍可能导致奖励预期增加和对不确定性的敏感性更高，这反过来可能会导致赌博成瘾行为。此外，冲动性增加（众所周知的赌博障碍风险因素）与多巴胺能功能障碍有关。最近，新出现的证据表明，多巴胺能药物可以影响延迟奖励的折扣。摘要多巴胺能药物可以提高长期目标相对于短期目标的重要性，可以改善患有赌博障碍的冲动个体的症状。更广泛地说，提高对具有明确神经生物学基础的中间行为和其他表型的理解可能有助于对赌博障碍和其他精神疾病进行个性化治疗。
Purpose of ReviewTo address variation in the severity of gambling disorder, this review evaluates the contribution of mesocorticolimbic dopamine neurons to potential behavioral endophenotypes, the influence of individual differences in the dopamine system on gambling and related behaviors, and the possible role for dopaminergic medications in the treatment of gambling disorder.Recent FindingsNewer work has suggested that dopaminergic dysfunction can lead to increased reward anticipation and a greater sensitivity to uncertainty, which in turn may drive addictive gambling behaviors. In addition, increased impulsivity, a well-recognized risk factor for gambling disorder, has been linked to dopaminergic dysfunction. More recently, emerging evidence has suggested that dopaminergic medications can influence the discounting of delayed rewards.SummaryDopaminergic drugs that increase the salience of long-term over short-term goals may ameliorate symptoms of impulsive individuals with gambling disorder. More broadly, improved understanding of intermediate behavioral and other phenotypes with a defined neurobiological substrate may allow for personalized treatment of gambling disorder and other psychiatric conditions.