Estimation of relative fitnesses from relative risk data and the predicted future of haemoglobin alleles S and C
Estimation of relative fitnesses from relative risk data and the predicted future of haemoglobin alleles S and C
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DOI：
10.1046/j.1420-9101.2003.00635.x
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发表时间：
2004-01-01
影响因子：
2.1
通讯作者：
Hedrick, P
中科院分区：
文献类型：
--
作者：
Hedrick, P
关于疾病易感性遗传差异的流行病学研究常常估计不同基因型的相对危险度（RR）。在这里，我提供了一种基于RR数据计算不同基因型的相对适应度的方法，以便可以利用这些数据使用群体遗传学方法。利用最近来自布基纳法索的人血红蛋白β基因型RR数据，该方法用于预测血红蛋白镰状细胞S和C等位基因频率的变化。总的来说，在疟疾环境中，等位基因C通常会迅速取代S等位基因。明确的种群遗传预测表明，在布基纳法索，这种替代可能在未来50代内发生。
Epidemiological studies of genetic differences in disease susceptibility often estimate the relative risks (RR) of different genotypes. Here I provide an approach to calculate the relative fitnesses of different genotypes based on RR data so that population genetic approaches may be utilized with these data. Using recent RR data on human haemoglobin beta genotypes from Burkina Faso, this approach is used to predict changes in the frequency of the haemoglobin sickle-cell S and C alleles. Overall, it generally appears that allele C will quickly replace the S allele in malarial environments. Explicit population genetic predictions suggest that this replacement may occur within the next 50 generations in Burkina Faso.