System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues
System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues
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DOI：
10.1117/1.jbo.18.3.036012
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发表时间：
2013-03-01
影响因子：
3.5
通讯作者：
Wells, Wendy A.
中科院分区：
文献类型：
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作者：
Laughney, Ashley M.;Krishnaswamy, Venkataramanan;Wells, Wendy A.
在手术时，在组织模拟体模和完全完整的乳房肿瘤切除术标本中评价了空间频域成像（SFDI）用于乳房手术切缘评估的可行性。根据对比度细节分辨率、定量准确度和模型数据拟合优度对体模数据进行评价，其中通过最小化测量的调制幅度及其解决方案之间的残差平方和来估计光学参数，根据扩散和缩放蒙特卡罗模拟进行建模。在对比度详细体模中，对于散射对比度>28%，可检测到直径为1.25 mm的表面夹杂物;对于10 mm的表面夹杂物，可检测到该散射对比度的一部分（7%），并且在体模表面以下1.5 mm处检测到至少33%的散射对比度，该探测深度与乳房手术切缘评估相关。除了在可见光波长处对总血红蛋白浓度的高估外，
The feasibility of spatial frequency domain imaging (SFDI) for breast surgical margin assessment was evaluated in tissue-simulating phantoms and in fully intact lumpectomy specimens at the time of surgery. Phantom data was evaluated according to contrast-detail resolution, quantitative accuracy and model-data goodness of fit, where optical parameters were estimated by minimizing the residual sum of squares between the measured modulation amplitude and its solutions, modeled according to diffusion and scaled-Monte Carlo simulations. In contrast-detail phantoms, a 1.25-mm-diameter surface inclusion was detectable for scattering contrast >28%; a fraction of this scattering contrast (7%) was detectable for a 10 mm surface inclusion and at least 33% scattering contrast was detected up to 1.5 mm below the phantom surface, a probing depth relevant to breast surgical margin assessment. Recovered hemoglobin concentrations were insensitive to changes in scattering, except for overestimation at visible wavelengths for total hemoglobin concentrations