Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b.
Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b.
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使用 GnuMoM2b 搜索和可视化妊娠性状的遗传关联。
DOI：
10.1093/genetics/iyad151
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发表时间：
2023
期刊：
影响因子：
3.3
通讯作者：
Radivojac,Predrag
中科院分区：
文献类型：
--
作者：
Yan,Qi;Guerrero,RafaelF;Khan,RaiyanR;Surujnarine,AndyA;Wapner,RonaldJ;Hahn,MatthewW;Raja,Anita;Salleb-Aouissi,Ansaf;Grobman,WilliamA;Simhan,Hyagriv;Blue,NathanR;Silver,Robert;Chung,JudithH;Reddy,UmaM;Radivojac,Predrag
不良妊娠结局(APO)是影响妇女怀孕期间甚至怀孕后数年健康的主要风险因素。由于载脂蛋白的异质性，目前只发现了很少的遗传关联。在这份报告中，我们使用了一项大型的种族多元化研究--无产妊娠结局研究：监测准妈妈(NuMoM2B)，对479个可能与APO有关的性状进行了全基因组关联研究(GWAS)。为了显示广泛的结果，我们开发了一个基于网络的工具GnuMoM2b(https://gnumom2b.cumcobgyn.org/))，用于搜索、可视化和共享来自479个妊娠性状的GWA结果，以及对1700多万个单核苷酸多态的表型关联研究。来自3个祖先(欧洲人、非洲人和混血的美国人)的遗传结果和荟萃分析被填充在GnuMoM2b中。总之，GnuMoM2b是提取与妊娠相关的遗传结果的宝贵资源，并显示出促进有意义的发现的潜力。
Adverse pregnancy outcomes (APOs) are major risk factors for women's health during pregnancy and even in the years after pregnancy. Due to the heterogeneity of APOs, only few genetic associations have been identified. In this report, we conducted genome-wide association studies (GWASs) of 479 traits that are possibly related to APOs using a large and racially diverse study, Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b). To display extensive results, we developed a web-based tool GnuMoM2b (https://gnumom2b.cumcobgyn.org/) for searching, visualizing, and sharing results from a GWAS of 479 pregnancy traits as well as phenome-wide association studies of more than 17 million single nucleotide polymorphisms. The genetic results from 3 ancestries (Europeans, Africans, and Admixed Americans) and meta-analyses are populated in GnuMoM2b. In conclusion, GnuMoM2b is a valuable resource for extraction of pregnancy-related genetic results and shows the potential to facilitate meaningful discoveries.