Effectiveness of the monovalent influenza A(H1N1)2009 vaccine in Navarre, Spain, 2009-2010: Cohort and case-control study
Effectiveness of the monovalent influenza A(H1N1)2009 vaccine in Navarre, Spain, 2009-2010: Cohort and case-control study
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DOI：
10.1016/j.vaccine.2011.06.063
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发表时间：
2011-08-11
期刊：
影响因子：
5.5
通讯作者：
Barricarte, Aurelio
中科院分区：
文献类型：
--
作者：
Castilla, Jesus;Moran, Julio;Barricarte, Aurelio
我们在西班牙的纳瓦拉使用医生的电子记录定义了一个基于人群的队列（596，755名受试者），以评估2009年甲型H1N1单价疫苗在2009-2010年流感大流行季节预防流感的有效性。在2009年甲型H1N1流感病毒疫苗供应和传播的9周期间，登记了4608例经医疗处理的流感样疾病（MA-ILI）病例（每1000人年46例）。在调整社会人口统计学协变量、门诊就诊和主要慢性病后，接种疫苗与MA-ILI总发病率降低32%（95%CI：8-50%）相关。在嵌套在队列中的测试阴性病例对照分析中，包括来自633名患者的拭子，其中123名被确认为A（H1N1）2009流感。没有确诊病例接种过甲型H1N1流感疫苗，而对照组为9.6%（p < 0.001）。在调整年龄、卫生保健环境、主要慢性疾病和时期后，疫苗预防实验室确诊流感的有效性为89%（95% CI：36-100%）。在2009-2010年季节，大流行疫苗有效预防了MA-ILI和2009年甲型H1N1流感确诊病例。(C)2011爱思唯尔有限公司版权所有。
We defined a population-based cohort (596,755 subjects) in Navarre, Spain, using electronic records from physicians, to evaluate the effectiveness of the monovalent A(H1N1)2009 vaccine in preventing influenza in the 2009-2010 pandemic season. During the 9-week period of vaccine availability and circulation of the A(H1N1)2009 virus, 4608 cases of medically attended influenza-like illness (MA-ILI) were registered (46 per 1000 person-years). After adjustment for sociodemographic covariables, outpatient visits and major chronic conditions, vaccination was associated with a 32% (95% CI: 8-50%) reduction in the overall incidence of MA-ILI. In a test negative case-control analysis nested in the cohort, swabs from 633 patients were included, and 123 were confirmed for A(H1N1)2009 influenza. No confirmed case had received A(H1N1)2009 vaccine versus 9.6% of controls (p < 0.001). The vaccine effectiveness in preventing laboratory-confirmed influenza was 89% (95% CI: 36-100%) after adjusting for age, health care setting, major chronic conditions and period. Pandemic vaccine was effective in preventing MA-ILI and confirmed cases of influenza A(H1N1)2009 in the 2009-2010 season. (C) 2011 Elsevier Ltd. All rights reserved.