Agitation and postdexamethasone cortisol levels in Alzheimer's disease.
Agitation and postdexamethasone cortisol levels in Alzheimer's disease.
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阿尔茨海默病中的躁动和地塞米松后皮质醇水平。
DOI：
10.1176/ajp.149.4.546
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Davis,KL
中科院分区：
文献类型：
--
作者：
Lawlor,BA;Tsuboyama,G;Ryan,T;Mohs,RC;Davis,BM;Davidson,M;Gabriel,S;Davis,KL
对 29 名可能患有阿尔茨海默病的患者进行了下丘脑-垂体-肾上腺 (HPA) 功能的临床相关性检查。这些患者的上午 8:00 地塞米松后皮质醇水平与较高的躁动评分高度相关，但与抑郁情绪或记忆障碍的程度无关。皮质醇增多症与阿尔茨海默病行为障碍之间关联的可能神经基础值得进一步探索和复制。
The clinical correlates of hypothalamic-pituitary-adrenal (HPA) functioning were examined in 29 patients with probable Alzheimer's disease. The 8: 00 am postdexamethasone cortisol levels of these patients were highly correlated with higher agitation scores but not with the degree of depressed mood or memory impairment. The possible neural basis for the association between hypercortisolism and behavioral disturbance in Alzheimer's disease warrants further exploration and replication.