DEFECTIVE PRESENTATION OF ENDOGENOUS ANTIGEN BY A CELL-LINE EXPRESSING CLASS-I MOLECULES
DEFECTIVE PRESENTATION OF ENDOGENOUS ANTIGEN BY A CELL-LINE EXPRESSING CLASS-I MOLECULES
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DOI：
10.1126/science.2326647
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发表时间：
1990-04-20
期刊：
影响因子：
56.9
通讯作者：
BEVAN, MJ
中科院分区：
文献类型：
--
作者：
HOSKEN, NA;BEVAN, MJ
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Cytotoxic T lymphocytes (CTLs) recognize class I major histocompatibility complex (MHC) molecules associated with antigenic peptides derived from endogenously synthesized proteins. Binding to such peptides is a requirement for class I assembly in the endoplasmic reticulum (ER). A mutant human celll ine, T2, assembles and transports to its surface some, but not all, class I MHC molecules. The class I molecules expressed on the surface of T2 do not present peptides derived from cytosolic antigens, although they can present exogenously added peptides to CTL. The transported class I molecules may interact weakly with an unknown retaining factor in the ER such that they can assemble despite the relative shortage of peptides.