The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling.
The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling.
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DOI：
10.1007/s11011-012-9283-0
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发表时间：
2012-06
影响因子：
3.6
通讯作者：
Pennypacker KR
中科院分区：
文献类型：
--
作者：
Seifert HA;Leonardo CC;Hall AA;Rowe DD;Collier LA;Benkovic SA;Willing AE;Pennypacker KR
与中风相关的延迟神经元死亡越来越多地与对损伤的免疫反应联系在一起。脾切除术前大脑中动脉闭塞（MCAO）是神经保护和显著减少神经炎症。本研究探讨了脾信号是否通过干扰素γ (IFNγ)发生。MCAO后，IFNγ在大鼠脾脏中早期升高，但在大脑中较晚升高。脾切除术可降低mcao后梗死灶中IFNγ的含量。全身给药重组IFNγ消除了脾切除术的保护作用，同时增加了大脑中ifγ的表达。这些结果提示脾源性IFNγ在脑卒中病理中的作用。
Delayed neuronal death associated with stroke has been increasingly linked to the immune response to the injury. Splenectomy prior to middle cerebral artery occlusion (MCAO) is neuroprotective and significantly reduces neuroinflammation. The present study investigated whether splenic signaling occurs through interferon gamma (IFNγ). IFNγ was elevated early in spleens but later in the brains of rats following MCAO. Splenectomy decreased the amount of IFNγ in the infarct post-MCAO. Systemic administration of recombinant IFNγ abolished the protective effects of splenectomy with a concurrent increase in INFγ expression in the brain. These results suggest a role for spleen-derived IFNγ in stroke pathology.