Interstitial pneumonitis following autologous bone marrow transplantation.
Interstitial pneumonitis following autologous bone marrow transplantation.
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自体骨髓移植后的间质性肺炎。
DOI：
10.1097/00007890-198807000-00010
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发表时间：
1988
期刊：
影响因子：
6.2
通讯作者：
Saral,R
中科院分区：
文献类型：
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作者：
Wingard,JR;Sostrin,MB;Vriesendorp,HM;Mellits,ED;Santos,GW;Fuller,DJ;Braine,HG;Yeager,AM;Burns,WH;Saral,R
143例接受细胞减灭术后自体骨髓移植治疗的恶性肿瘤患者中，20例发生间质性肺炎(IP)，发生率为14%。中位发病时间为41天(5~624天)。除了三起之外，所有的病例都是致命的。在对组织进行检查的13例病例中，有一半是特发性的，其余的是由各种感染源引起的。这些自体骨髓移植受者的特发性(7%)和巨细胞病毒感染(2%)发生率低于接受同种异体骨髓移植对照治疗的患者(19%)和巨细胞病毒感染(17%)，≤0.001。
Interstitial pneumonitis (IP) occurred in 20 of 143 14%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the thirteen cases in which tissue was examined, half were idiopathic; the remainder were due to various infectious agents. The lectuarial incidences of idiopathic (7%) and CMV IP (2%) these marrow autograft recipients were lower than he incidences of idiopathic (19%) and CMV IP (17%) in comparably treated recipients of allogeneic BMT p≤ 0.001 for both comparisons).