Structural mechanisms of the agrin-LRP4-MuSK signaling pathway in neuromuscular junction differentiation.
Structural mechanisms of the agrin-LRP4-MuSK signaling pathway in neuromuscular junction differentiation.
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DOI：
10.1007/s00018-012-1209-9
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Jin R
中科院分区：
文献类型：
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作者：
Zong Y;Jin R
神经肌肉接头（NMJ）是神经元突触发生研究最广泛的模型。乙酰胆碱受体（AChR）在突触后膜上的聚集是神经肌肉接头分化的重要事件。乙酰胆碱受体的聚集和突触后分化是由三种蛋白质之间复杂的相互作用协调的：神经元分泌的蛋白聚糖聚集蛋白，辅助受体LRP 4和肌肉特异性受体酪氨酸激酶MuSK。LRP 4和MuSK作为多个结合伙伴的支架，导致AChR聚类所需的相互作用蛋白质的复杂和动态网络。本文就agrin-LRP 4-MuSK信号通路介导的NMJ突触后分化的结构基础进行综述。
The neuromuscular junction (NMJ) is the most extensively studied model of neuronal synaptogenesis. Acetylcholine receptor (AChR) clustering on the postsynaptic membrane is a cardinal event in the differentiation of NMJs. AChR clustering and postsynaptic differentiation is orchestrated by sophisticated interactions among three proteins: the neuron-secreted proteoglycan agrin, the co-receptor LRP4, and the muscle-specific receptor tyrosine kinase MuSK. LRP4 and MuSK act as scaffolds for multiple binding partners, resulting in a complex and dynamic network of interacting proteins that is required for AChR clustering. In this review, we discuss the structural basis for NMJ postsynaptic differentiation mediated by the agrin-LRP4-MuSK signaling pathway.